FRIDAY OCTOBER 17, 2003 8:00 AM - 5:30 PM

8:00 - 8:15 AM Welcome - Kamil Ugurbil

8:15 - 9:15 AM Clinical Systems - Moderator: J. Thomas Vaughan

• 8:15-8:35 Douglas Kelly, GE Medical Systems
• 8:35-8:55 Peter Luyten, Philips Medical Systems
• 8:55-9:15 Franz Schmidt, Siemens Medical Systems

9:15 - 11:30 AM Static & RF Fields in Human Body - Moderator: Rolf Gruetter

• 9:15-9:45 Gary Glover
  "Shimming for MRI/S"
• 9:45-10:15 Andrzej Jesmanowicz
  "Reasons to Shim"

• 10:30-11:00 Piotr Starewicz
  "Magnetic Field Shimming - The Impossible Task"
• 11:00-11:30 Michael B. Smith
  "High Field Distortions of the Static and Radio Frequency Field: The Good, The Bad, and The Ugly"

11:30 - 1:00 PM High Field Imaging - Moderator: Kamil Ugurbil

• 11:30 - 12:00 Juergen Hennig
  "Methodological Approaches to Deal with SAR-Issues in High Field Imaging"
• 12:00 - 12:30 Haiying Liu
  "High Field MR Imaging: Preliminary Experiences"
• 12:30 - 1:00 J. Thomas Vaughan
  "RF Problems and Solutions for High Field Imaging"

1:00 - 2:00 PM LUNCH

2:00 - 5:30 PM High Field Proton Spectroscopy - Moderator: Michael Garwood

• 2:00-2:30 Ivan Tkac
  "In Vivo ¹H NMR Spectroscopy at High Magnetic Fields"
• 2:30-3:00 Peter Allen
  "Prospective Spectroscopic Sequence Design for Different Field Strengths"
• 3:00-3:30 Melissa Terpstra
  In Vivo ¹H Edited Spectroscopy at High Magnetic Fields: Advantages, Advances, and Applications to GABA, GSH, and Vitamin C"

• 4:00-4:30 In-Young Choi
  "Multiple Quantum Coherence Transfer MR Spectroscopy in Vivo"
• 4:30-5:00 Patrick Bolan
  "Quantitative MRS of the Breast at 4T"
• 5:00-5:30 Daniel Vigneron
  "High Resolution Phased-array MR Spectroscopic Imaging and SSFSE-DTI of the Brain and Prostate"

6:30 - 8:30 PM RECEPTION AT THE CMRR

SATURDAY OCTOBER 18, 2003 8:00 AM - 5:00 PM

8:00 - 10:00 AM Parallel Imaging - Moderator: Gregor Adriany

• 8:00-8:30 Klaas Pruessmann
  "Opportunities and Challenges of Parallel MRI at High Field"
• 8:30-9:00 Pierre-Francois van de Moortele
  "Whole Brain echo Planar Imaging at Ultra High Field? How RF Coil Design and Parallel Imaging can Impact the Challenge"
• 9:00-9:30 Daniel Sodickson
  "Coil Array Design for Parallel Imaging: General Principles and High-Field Prospects"

9:30-10:00 AM BREAK

10:00 - 12:00 PM Relaxation - Moderator: Shalom Michaeli

• 10:00-10:30 Pierre Gillis
  "From Relaxation Induced by Magnetized Inclusions to the Ferritin Enigma"
• 10:30-11:00 William Rooney
  "Brain Physiology Revealed Through ¹H₂O R1 Measurements"
• 11:00-11:30 Risto Kauppinen
  "Applications of T₁ in the Rotating Frame (T_1&rho) MRI to Studies of Acute Experimental Stroke"
• 11:30-12:00 Denis le Bihan
  "Diffusion MRI: An Alternative to BOLD fMRI to Investigate Brain Function?"

12:00 - 1:00 PM LUNCH

1:00 - 5:00 Exogeneous Contrast Agent and Molecular Imaging - Moderator: Itamar Ronen

• 1:00-1:30 David Kleinfeld
  "Optical-Based Imaging and Manipulation of Cortical Blood Flow in Rat"
• 1:30-2:00 Thomas Meade
  "The Chemistry of Bimolecular Molecular Imaging"
• 2:00-2:30 Charles S. Springer
  "The NMR Shutter-Speed: From Chemistry to Cancer, and Beyond"

• 3:00-3:30 Joseph Mandeville
  "Functional MRI using Exogenous Contrast Agent"
• 3:30-4:00 Noam Harel
  "Specificity of CBV-weighted fMRI Signals"
• 4:00-4:30 Jeffrey Bulte
  "Tracking of Magnetically Labeled Progenitors and Stem Cells"
• 4:30-5:00 Clifford Jack
  "MR Imaging of Contrast Enhanced Alzheimer's Amyloid Plaques"

6:30 PM Dinner Radisson

• Speaker: Timothy J. Ebner, MD, PhD
• Chairman; Dept of Neuroscience
• University of Minnesota
• "Optical Imaging of Cerebellar Cortical Functional Architectures"

SUNDAY OCTOBER 19, 2003 8:30 AM - 5:30 PM

8:30 - 10:30 Functional Imaging with Non-BOLD Intrinsic Signal - Moderator: Pierre-Francois van de Moortele

• 8:30-9:00 Alan Song
  "Functional MRI using Dynamic ADC Contrast"
• 9:00-9:30 Peter Fox
  "Magnetic Source MRI (msMRI): magnet Resonance Imaging Magnetic Fields Induced by Neuronal Firing"
• 9:30-10:00 Peter van Zjil
  "Vascular-Space-Occupancy (VASO) Dependent fMRI: Theory, Implementation, and Spatial/Temporal Characterization"
• 10:00-10:30 Peter Bandettini
  "Neuronal Current Imaging"

10:30-11:00 AM BREAK

11:00 - 1:00 PM fMRI-Spatial Specificity / High Resolution Application - Moderator: Wei Chen

• 11:00-11:30 Seong-Gi Kim
  "Column and Layer-specific Functional Mapping using Perfusion Imaging Contrast"
• 11:30-12:00 Ravi Menon
  "The BOLD Signal: Spatial Resolution Limits"
• 12:00-12:30 Essa Yacoub
  "Specificity of BOLD fMRI at High Fields for Sub-millimeter Spatial Resolution Applications in Humans"
• 12:30-1:00 Afonso Silva
  "Probing Laminar Heterogeneity of fMRI Onset Times in Rat Somatosensory Cortex at High Spatial and Temporal Resolution"

1:00 - 2:00 PM LUNCH

2:00 - 5:30 PM Functional Energetics and Signal Origin - Moderator: Kamil Ugurbil

• 2:00-2:30 Seiji Ogawa
  "An fMRI Study of Dynamic Aspects of Fast Interaction Among Systems in a Functional Network"
• 2:30-3:00 Britton Chance
  "Oxygen Extraction Changes During Functional Activity of Prefrontal Cortex (PFC)"
• 3:00-3:30 Martin Lauritzen
  "Brain Function and Neurophysiological Correlates of Signals used in Functional Neuroimaging"
• 3:30-4:00 Pierre Magistretti
  "Brain Metabolism: Evidence for Neuronal/Glial Coupling and Relevance for Functional Imaging"

• 4:30-5:00 Robert G. Shulman
  "Implications of Baseline Neuronal Activity for fMRI and Consciousness"
• 5:00-5:30 Rolf Gruetter
  "Brain Glycogen and Compartmentalized Neurotransmitter Fluxes in Vivo"

MONDAY OCTOBER 20, 2003 8:00 AM - 3:30 PM

8:00 - 10:30 AM Multi-nuclear Brain Spectroscopy - Moderator: Michael Garwood

• 8:00-8:30 Hoby Hetherington
  "Multi-nuclear Spectroscopic Imaging in Temporal Lobe Epilepsy"
• 8:30-9:00 Wei Chen
  "In Vivo ³¹P NMR Spectroscopy of Human Brain at 7T"
• 9:00-9:30 Robin deGraaf
  "In Vivo ¹H-[¹³C]-NMR Spectroscopy of Cerebral Metabolism"
• 9:30-10:00 Pierre-Gilles Henry
  "Measuring and Modeling ¹³C Isotopic Turnover in the Brain"
• 10:00-10:30 Xiao-Hong Zhu
  "In Vivo ¹⁷O NMR at High Field"

10:30-11:00 AM BREAK

11:00 - 3:30 PM Connectivity - Moderator: Xiaoping Hu

• 11:00-11:30 Joseph Ackerman
  "The NMR Diffusion Signal: A Road Map to SubVoxel MicroStructure or Quicksand for Model Builders"
• 11:30-12:00 Susumu Mori
  "Information about White Matter Anatomy and Integrity Revealed by DTI"

• 1:00-1:30 Dae-Shik Kim
  "In Vivo Visualization of Axonal Connectivity and Functional Activity using Diffusion Tensor MRI"
• 1:30-2:00 Itamar Ronen
  "Diffusion Components and Tissue Compartments - Where is the (Axonal) Connection?"
• 2:00-2:30 Carlo Pierpaoli
  "Can We Investigate Anatomical Connectivity Using Diffusion MRI Methods?"
• 2:30-3:00 Michael Moseley
  "Applications of DTI in Cognition"
• 3:00-3:30 Van Wedeen
  "Imaging Neural Architecture and Connectivity with Diffusion Spectra"

3:30 Closing Remarks - Kamil Ugurbil

fMRI TRAINING COURSE October 21-22, 2003

fMRI Data Acquisition at 4T and 7T

• Block-design fMRI data collection
• Perfusion Contrast
• Single-trial data collection

fMRI Processing

• Processing of block-design data - Stimulate
• Processing of single-trial data